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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
RPS6KA4
All Species:
44.24
Human Site:
T178
Identified Species:
64.89
UniProt:
O75676
Number Species:
15
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75676
NP_001006945.1
772
85606
T178
S
E
G
H
I
V
L
T
D
F
G
L
S
K
E
Chimpanzee
Pan troglodytes
XP_508900
901
98668
T307
S
E
G
H
I
V
L
T
D
F
G
L
S
K
E
Rhesus Macaque
Macaca mulatta
XP_001114877
772
85557
T178
S
E
G
H
I
V
L
T
D
F
G
L
S
K
E
Dog
Lupus familis
XP_854926
772
85603
T178
S
E
G
H
I
V
L
T
D
F
G
L
S
K
E
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z2B9
773
85721
T178
S
E
G
H
I
V
L
T
D
F
G
L
S
K
E
Rat
Rattus norvegicus
Q63531
735
82865
T204
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506738
716
80894
A169
M
Y
E
L
L
T
G
A
S
P
F
T
V
D
G
Chicken
Gallus gallus
Q5F3L1
789
89022
T184
S
D
G
H
V
V
L
T
D
F
G
L
S
K
E
Frog
Xenopus laevis
P10665
733
82620
T204
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
Zebra Danio
Brachydanio rerio
Q6PFQ0
740
83378
T209
E
A
G
H
I
K
L
T
D
F
G
L
S
K
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9V3I5
1207
137026
S406
G
E
G
H
I
V
L
S
D
F
G
L
S
K
I
Honey Bee
Apis mellifera
XP_395099
910
102507
T209
K
E
G
H
I
V
L
T
D
F
G
L
S
K
E
Nematode Worm
Caenorhab. elegans
Q18846
772
87050
E186
N
S
Y
C
G
T
I
E
Y
M
S
P
E
V
I
Sea Urchin
Strong. purpuratus
XP_786494
918
102561
S200
N
K
A
V
D
W
W
S
L
G
V
L
T
Y
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q39030
471
53019
Baker's Yeast
Sacchar. cerevisiae
P18961
677
76646
A160
S
N
D
A
S
E
V
A
A
I
M
R
Q
L
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85.4
98.6
96.7
N.A.
95.8
41.3
N.A.
56
64
41
41.9
N.A.
27
45.1
48.1
48.2
Protein Similarity:
100
85.6
98.9
98
N.A.
96.7
60.6
N.A.
71.6
78.4
59
60.3
N.A.
38.9
60.1
64.3
61.8
P-Site Identity:
100
100
100
100
N.A.
100
86.6
N.A.
0
86.6
86.6
80
N.A.
80
93.3
0
13.3
P-Site Similarity:
100
100
100
100
N.A.
100
86.6
N.A.
6.6
100
86.6
80
N.A.
86.6
93.3
13.3
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
20.4
21.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
35.6
37.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
7
7
0
0
0
13
7
0
0
0
0
0
0
% A
% Cys:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
7
7
0
7
0
0
0
69
0
0
0
0
7
0
% D
% Glu:
19
57
7
0
0
7
0
7
0
0
0
0
7
0
69
% E
% Phe:
0
0
0
0
0
0
0
0
0
69
7
0
0
0
0
% F
% Gly:
7
0
69
0
7
0
7
0
0
7
69
0
0
0
7
% G
% His:
0
0
0
69
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
63
0
7
0
0
7
0
0
0
0
13
% I
% Lys:
7
7
0
0
0
19
0
0
0
0
0
0
0
69
0
% K
% Leu:
0
0
0
7
7
0
69
0
7
0
0
75
0
7
0
% L
% Met:
7
0
0
0
0
0
0
0
0
7
7
0
0
0
0
% M
% Asn:
13
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
7
0
7
0
0
7
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% R
% Ser:
44
7
0
0
7
0
0
13
7
0
7
0
69
0
0
% S
% Thr:
0
0
0
0
0
13
0
63
0
0
0
7
7
0
0
% T
% Val:
0
0
0
7
7
50
7
0
0
0
7
0
7
7
0
% V
% Trp:
0
0
0
0
0
7
7
0
0
0
0
0
0
0
0
% W
% Tyr:
0
7
7
0
0
0
0
0
7
0
0
0
0
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _